How to Uninstall Microsoft Office Desktop Apps Press Windows+X (the windows button is between left Ctrl and left Alt). In the menu that opens left click App and Features. The Apps and Features window will open. Scoll down the list and click on the Microsoft Office Desktop Apps/Microsoft 365 Apps for Enterprise entry in the Apps and Features window to expand it. Left click on the Uninstall button in the expanded entry. Follow the prompts to complete the uninstall.